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Please use this identifier to cite or link to this item: http://ir.calis.edu.cn/hdl/530500/17575

Title: 培养南海红树林内源真菌Fusarium sp. ZZF60产新型蒽醌衍生物
Other Titles: New Anthraquinone Derivative Produced by Cultivation of Mangrove Endophytic Fungus Fusarium sp. ZZF60 from the South China Sea
Authors: 广西民族大学化学与生态工程学院
中山大学化学与化学工程学院
广西师范大学化学化工学院
三峡大学化学与生命科学学院
黄忠京
杨瑞云
郭志勇
佘志刚
林永成
Keywords: 红树林内生真菌
ZZF60
代谢产物
蒽醌
抗肿瘤活性
Issue Date: 2010-04-10
Publisher: 应用化学
Citation: 应用化学,2010,27(4);394-397
Abstract: 通过人工发酵培养,从南海红树林内源真菌Fusarium sp.ZZF60的培养液中分离得到:1种新蒽醌衍生物,6,8-二甲氧基-1-甲基-2-(3-氧丁基)蒽醌(1),以及5种已知化合物:7-羟基-3-(4-甲氧基苯基)苯并-γ-吡喃酮(2),2,4-二羟基-6-[(1′E,3′E)-1′,3′-戊二烯基]苯甲醛(3),(E)-4-羟基肉桂酸甲酯(4),4-(4-羟基苯基)-2-丁醇(5),4-羟基苯甲酸(6)。它们的结构通过MS、NMR等波谱分析推导确定。初步药理活性显示,化合物1抑制体外培养人喉癌细胞Hep2和人肝癌细胞HepG2的IC50分别为16和23μmol/L。 A new anthraquinone derivative,6,8-dimethoxy-1-methyl-2-(3-oxobutyl) anthrakunthone(1),together with five known compounds,7-hydroxy-3-(4-methoxyphenyl)-chromen-4-one(2),2,4-dihydroxy-6-[(1′E,3′E)-penta-1′,3′-dienyl]-benzaldehyde(3),(E)-4hydroxycinnamic acid methyl ester(4),4-(4-hydroxyphenyl)-butan2-ol(5),and 4-hydroxybenzoic acid(6),were isolated from the marine mangrove endophytic fungus Fusarium sp.ZZF60 from the South China Sea.Their structures were elucidated by spectral data of IR,MS and NMR.In the preliminary bioassay,compound 1 showed cytotoxicity towards Hep2 and HepG2 with IC_50 values of 16 μmol/L and 23 μmol/L,respectively.
URI: http://ir.calis.edu.cn/hdl/530500/17575
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