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Please use this identifier to cite or link to this item: http://ir.calis.edu.cn/hdl/530500/17577

Title: 一个新的苯并-γ-吡喃酮衍生物来源于南海红树林内生真菌ZZF41
Other Titles: A New Chromone Derivative Isolated from the Marine Mangrove Endophytic Fungus ZZF41
Authors: 广西民族大学化学与生态工程学院
中山大学化学与化学工程学院
中山大学生命科学学院
黄忠京
佘志刚
蔡小玲
林永成
周世宁
Keywords: 红树林内生真菌
苯并-γ-吡喃酮衍生物
环肽
代谢产物
Issue Date: 2009-11-15
Publisher: 中山大学学报(自然科学版)
Citation: 中山大学学报(自然科学版),2009,06:63-68
Abstract: 1个新的苯并-γ-吡喃酮衍生物,3,5-二羟基-2-甲基-6-(3-甲基-2-丁烯基)苯并-γ-吡喃酮(1),以及1个结构独特的环四肽(2)和3个环二肽,从南海红树林内生真菌ZZF41代谢产物中分离得到。它们的结构通过MS、NMR等波谱分析推导确定。化合物1对人鼻咽癌细胞株KB和人鼻咽癌细胞耐药株KBV200显示了微弱的细胞毒活性(IC50均大于50μg/mL),而2对同样细胞株有细胞毒活性(IC50均小于3.56μg/mL)。A new chromone derivative named as 5-dihydroxy-2-methyl-6- (3-methylbut-2- enyl) -4H- chromen-4-one (1), a novel cyclic tetrapeptide (2) and three cyclic dipeptides were isolated from the mangrove endophytie fungus ZZF41 from the South China Sea. Their structures were characterized by MS, NMR. Compound 1 exhibited weak cytotoxicity towards KB and KBv200 with ICs0values of more 50 μg/mL. Compound 2 showed cytotoxicity towards KB and KBv200 with IC50 values of less 3.56 μg/mL, respectively.
URI: http://ir.calis.edu.cn/hdl/530500/17577
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